
The following conditions cause cell death due to poor perfusion.
- Myocardial infarction—A clot in one of the heart arteries stops blood with oxygen from continuing.
- Cerebral vascular accident—A clot in one of the brain arteries stops blood with oxygen from continuing.
- Peripheral vascular disease—A clot in one of the arm or leg arteries stops blood with oxygen from continuing.
- Severe infection (sepsis)—Immune response causes blood vessels to dilate, bringing blood pressure lower than 60 MAP.
- Traumatic event with blood loss—Not enough blood is available to transport oxygen.

The following conditions do not cause cell death due to poor perfusion.
- Deep vein thrombosis—Although this problem is caused by a blockage, it means stopping unoxygenated blood from returning to the heart. The blood with oxygen is still getting to the tissue.
- Diabetes—Although diabetes stops glucose from getting into the cells, it does not block oxygen. Cells lack energy, not oxygen.
- Kidney failure—This causes toxins to build up in the blood and does not cause perfusion problems.
- Hypertension—This can lead to problems such as heart disease, but it does not cause poor perfusion by itself.
- Allergic rhinitis—This causes a runny nose, not a tissue perfusion problem.